The Atlanta Falcons defeated the San Francisco 49ers 29-20 in their 2026 season opener. Quarterback Michael Penix Jr. Threw for three touchdowns. The Falcons' defense forced four turnovers. The game took place on Sunday afternoon. The victory marks the 49ers' first loss of the 2026 season. Penix completed 21 of 30 passes for 247 yards. The Falcons' defense recorded two sacks and two interceptions. The 49ers' offense struggled to move the ball. The game was played at Mercedes-Benz Stadium in Atlanta. The Falcons improved to 1-0. The 49ers fell to 0-1. The result sets the tone for the NFL season.