The New York Giants are set to take on the Tennessee Titans in Week 3 of the NFL season, with quarterback Jameis Winston making his first start of the year. The matchup promises to be a key test for the Giants, who will look to capitalize on their depth at running back and the emerging play of rookie Dominic Zvada. Winston, who has shown promise in limited action, will be under center for the first time this season, adding an element of unpredictability to the Giants' offense. The Titans, meanwhile, will be eager to maintain their strong start to the season, with their defense expected to be a major factor in the game. The contest will take place at MetLife Stadium in East Rutherford, New Jersey, and is expected to draw a large crowd. Both teams will be looking to secure a win in a matchup that could have significant implications for their standings in the AFC East.